http://www.mamaherb.com/Treatments/View.aspx?id=5632
The following combination of supplements have been shown in studies to not only potentiate standard antibiotic treatment (especially helpful for drug-resistant TB), but to cure TB in most cases on their own:

600mg vitamin C per day;

75,000-150,000 iu (units) of Vitamin A;

vitamin K2 (this is made by intestinal flora -- if you can't obtain K2, eating greens and taking probiotics will help you make more K2;

5000-10000 iu of vitamin D3 (Cholecalciferol) (cod-liver oil has vitamins A & D). Be careful if you take too much D3 along with too much calcium: your serum Calcium may go too high. I've found that the 200mg Calcium in Activite Sport and getting the rest of the calcium from raw organic blenderized leafy greens and other specific vegetables, along with 5000iu of D3 (in oil -- D3 is oil-soluble, so don't buy dry powders as they are not absorbed very well) was sufficient to push serum calcium up to 10.3 but still be within normal range (enough to help but not to harm), but you may need a little more or less depending upon your blood tests. Vitamin D3 not only helps your immune system to prevent and fight TB and illnesses from other pathogens and cancer; it helps keep Latent (or Dormant) TB from becoming Active, so relativese and close contacts might also want to take D3. Having lower D3 blood levels from less sunlight is the reason why many immigrants from tropical countries to countries with less direct sunlight suddenly find themselves with Active TB 3-4 months after they leave the tropical countries. (Also see article below re D3).

4g/day brewer's yeast;

Zinc;

N-Acetyl Cysteine (NAC);

A good IRON-FREE multivitamin/multimineral with vitamins B6, B12, E, folic acid, pantothenate, etc.



Vitamin D3 is important to fight infections.
Country Life, Gluten Free, Vitamin D3, 5,000 I.U., 200 Softgels (CLF-05808), $10.79
http://www.iherb.com/Country-Life-Gluten-Free-Vitamin-D3-5-000-I-U-200-Softgels/18038

TB, Calcium levels & Supplements, Vitamin D3, K2, Ebola and Infectious Disease Processes

If you are worried about this year’s influenza pandemic predicted by the CDC or are in fear for your family’s safety because of the Ebola virus then calculate in vitamin D supplementation as well as Vitamin C, K2, magnesium, iodine, selenium, bicarbonate and other important nutrients... (see full article for dosages and more info.)

Too much Vitamin D can cause dangerously high calcium levels. when supplementing a diet with D3 and K2 you should never take calcium supplements; just eat a normal healthy diet [don't take any extra supplemental calcium than is in a good multivitamin/mineral such as Activite Sport (that contains 200mg calcium, along with Mg, Zn, Mn, Bo, and other essential co-factors needed to put calcium in the bones and teeth -- not in the soft tissues, and get the rest of your calcium from a very healthy diet, including specific Vitamix blenderized raw, organic vegetables.]
http://drsircus.com/medicine/vitamin-d-ebola-infectious-disease-processes
http://drbenkim.com/vitamin-d-facts.htm

Vitamin D and TB
TB is also a major global problem: Nine million people a year develop the active disease worldwide, which kills two million each year. Scientists have shown that a single 2.5mg dose of vitamin D may be enough to boost the immune system to fight against tuberculosis (TB) and similar bacteria for at least 6 weeks. Their findings came from a study that identified an extraordinarily high incidence of vitamin D deficiency amongst those communities in London most at risk from the disease, which kills around two million people each year.

The research, funded by the Department of Environmental Health and Newham University Hospital. Dr Adrian Martineau from the Imperial College London, who co-ordinated the study said, “Our work adds to the growing evidence that vitamin D may have a wide range of important health benefits, including preventing falls and fractures and reducing risk of cancer and diabetes, as well as boosting the immune system against infection. Population-wide supplementation needs to be considered by public health planners."
Excerpts -- see full articles at links:
http://drsircus.com/medicine/vitamin-d-ebola-infectious-disease-processes
http://drbenkim.com/vitamin-d-facts.htm

Note: because my levels of vitamin D3 were low, I initially took 50,000 iu of vitamin D3, then 7,500 iu/day from then on (one 5,000 iu every day, and one every other day; average = 7500iu/d)


Progress with TB or a Return to the Dark Ages?

This article may be reprinted free of charge provided 1) that there is clear attribution to the Orthomolecular Medicine News Service, and 2) that both the OMNS free subscription link http://orthomolecular.org/subscribe.html and also the OMNS archive link http://orthomolecular.org/resources/omns/index.shtml are included.

FOR IMMEDIATE RELEASE
Orthomolecular Medicine News Service, June 17, 2013
Progress with TB or a Return to the Dark Ages?
by Steve Hickey, PhD and William B. Grant, PhD

(OMNS June 17, 2013) Tuberculosis (TB) was formerly one of the most devastating scourges of mankind and remains a leading cause of death. The disease has been with humans over recorded history, and likely throughout the evolution of our species. Through the industrial revolution and into the 20 century, TB became a long term medical emergency particularly with the poor. Roughly one person in four was dying of the disease in England and similar death rates were observed in other modernising countries. One solution was to isolate the afflicted in sanatoria. The fresh air and sunlight solution practiced in those times may have been at least partly effective.

Sunlight and vitamin D played an early role in preventing and treating TB. In the early 20th century, TB patients were often sent to sanatoria in the mountains where they were exposed to solar radiation. Dr. Auguste Rollier set up such facilities in the Swiss Alps. [1] Sun exposure is associated with a lower incidence of TB six months later. [2]. It wasn't until 2006-7 that researchers at UCLA determined how sunlight increased vitamin D levels and helps the body's immune system prevent bacterial infections [3]. Higher blood levels of 25-hydroxyvitamin D can reduce the time required to control TB during treatment. [4,5] Recent research suggests the sanatoria approach to treatment could have been at least partly effective.

The modern myth about conquering infectious diseases such as TB is that vaccination and antibiotics came to the rescue, saving humanity from the earlier suffering. However, TB like the other major life threatening infections had already declined to a low level before these interventions were introduced. The tubercle bacillus was identified by Robert Koch in 1882 [6] by which time the death rates in England and Wales had already reduced to about half the earlier levels. The introduction of the drug isoniazid in the early 1950s was a breakthrough in antibiotic treatment but had little effect on overall mortality. Similarly, BCG vaccination was first tried in people in the early 1920s but its widespread introduction was delayed until well after World War 2. A chart of mortality from TB shows its historical decline in England and Wales for which the most extensive historical statistics are available. [7] The decline of TB was similar to the reduction in mortality for the other major infectious diseases. This graph illustrates the relative contribution of vaccination and antibiotic chemotherapy. By the time these interventions had been introduced, the major infections had already been largely defeated.

The question raised by this graph is what really caused the decline in death rates from TB and other infections. We can answer this easily and directly. Firstly, TB did not go away. There is a reasonable chance that a reader is harbouring the disease. Roughly one person in every three in the world (2-3 billion) has the infection. However, only 10-20 million have the active disease. So only one person in every 100 or so infected will have any symptoms. The rest will happily coexist with their "infection" without concern.

TB Mortality Per Million

http://www.orthomolecular.org/resources/omns/v09n12-graph.jpg

TB Mortality Per Million

http://www.orthomolecular.org/resources/omns/v09n12-graph.jpg

People who come down with TB have poor or compromised immune systems. The disadvantaged were living in crowded and damp slum conditions. Although such conditions facilitate spread of the infection this explanation is insufficient. Poor nutrition provides a more direct explanation of why only some of the infected go on to succumb to the illness.
TB and Vitamin C

Despite the data strongly suggesting the impact of nutrition, corporate medicine has consistently decried the use of supplements. Recently, however, there has been a long overdue development. Catherine Vilchèze and colleagues have returned to testing the extraordinary antibiotic properties of vitamin C for TB.[8] They was found that "M. tuberculosis is highly susceptible to killing by vitamin C" [3] which is consistent with previous data. [9] Notably, the mechanism of action is similar to vitamin C's anticancer role in generating hydrogen peroxide locally which kills the unwanted cells. [10] Notably, we have been using antibiotic treatment of TB as a model for the role of vitamin C based redox therapy for cancer. The same mechanism is used to protect the body against both microorganisms and abnormal cancer cells.

Supplementation with vitamin C may prevent TB infection from becoming overt. Furthermore, vitamin C could provide an effective biological treatment for TB with the advantage of a mechanism refined by millions of years of evolution. As scientific history demonstrates, good nutrition, particularly vitamins C and D, are likely to be far more effective than antibiotics and vaccination in preventing this and other dangerous infective diseases.

Vilcheze's suggests that drugs with a similar mechanism of action to vitamin C might be developed (presumably with great commercial advantage). However, such drugs are an unnatural intervention, and are likely to have unnecessary side-effects while vitamin C is safe. The rather obvious implication of providing high-dose nutritional supplements is once again ignored. If supplementation were to be widely applied, our society may find controlling TB is unexpectedly easy.

The recent history of antibiotics is one of misuse leading to microbial resistance. Following Multiple Drug Resistant TB (MDRTB) and eXtensively drug resistant forms (XDRTB) we are now faced with Totally Drug Resistant forms (TDRTB). The increasingly ineffective antibiotics have helped promote the return to study vitamin C as a potential treatment. However, we may be faced with something far more threatening. The history of antibiotic abuse is not reassuring. It may be possible to generate more virulent forms despite Vilcheze's confirmation that resistance to vitamin C is exceptionally difficult to induce. The use of drugs with a similar mechanism to vitamin C may lead to resistance to our basic biological defence mechanisms. In other words, corporate misuse of this latest development could return us to the dark days of uncontrolled infections when TB was killing 1 in 4 people in the developed nations.
Conclusion

Much of the recent freedom from deadly infectious disease reflects historical improvements in nutrition. Over time the mechanisms by which nutrients help people be more resistant to infections are being elucidated. Increased levels of vitamin D may have provided a lower risk of TB and other infections as well as the deficiency disease rickets. It now appears that vitamin C is "extraordinarily" effective in killing the TB microorganism. Importantly vitamin C kills TB in essentially the same way as it destroys cancer cells. Linus Pauling, Robert Cathcart and others may have been prescient in suggesting vitamin C provides a unique way of maintaining good health.

For further reading:

To access forty years of articles describing orthomolecular approaches to health management and treatment of disease visit http://orthomolecular.org/library/jom/

References:

1. Hobday R.A. (1997) Sunlight therapy and solar architecture, Med Hist, 41(4), 455-472.

2. Koh G.C. Hawthorne G. Turner A.M. Kunst H. Dedicoat M. (2012) Tuberculosis incidence correlates with sunshine: an ecological 28-year time series study, PLoS One, 8(3), e57752.

3. Liu P.T. Stenger S. Tang D.H. Modlin R.L. (2007) Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin, J Immunol, 179(4), 2060-2063.

4. Sato S. Tanino Y. Saito J. Nikaido T. Inokoshi Y. Fukuhara A. Fukuhara N. Wang X. Ishida T. Munakata M. (2012) The relationship between 25-hydroxyvitamin D levels and treatment course of pulmonary tuberculosis, Respir Investig, 50(2), 40-45.

5. Coussens A.K. Wilkinson R.J. Hanifa Y. Nikolayevskyy V. Elkington P.T. Islam K. Timms P.M. Venton T.R. Bothamley G.H. Packe G.E. Darmalingam M. Davidson R.N. Milburn H.J. Baker L.V. Barker R.D. Mein C.A. Bhaw-Rosun L. Nuamah R. Young D.B. Drobniewski F.A. Griffiths C.J. Martineau A.R. (2012) Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment, Proc Natl Acad Sci U S A, 109(38),15449-15454.

6. Mörner K.A.H. (2005) Nobel Prize in Physiology or Medicine 1905, Presentation Speech, www.nobelprize.org/nobel_prizes/medicine/laureates/1905/press.html.

7. McKeown T. (1979) The Role Of Medicine, Blackwell.

8. Vilchèze C. Hartman T. Weinrick B. Jacobs W.R. (2013) Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction, Nature Communications, doi:10.1038/ncomms2898.

9. Hickey S. Saul A.W. (2008) Vitamin C: The Real Story, the Remarkable and Controversial Healing Factor, Basic Health.

10. Hickey S. Roberts H. (2013) Vitamin C and cancer: is there a role for oral vitamin C? JOM, 28(1), 33-46.

Nutritional Medicine is Orthomolecular Medicine

Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

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Cheap and Effective TB Drug Being Ignored: Researchers Find Low Cost Drug Wipes Out Drug Resistant TB, But Worry it May Not Reach Patients in Need
http://www.anh-usa.org/reader%e2%80%99s-corner-cheap-and-effective-tb-drug-being-ignored-action-alert/

The links go to articles that explain that these over the counter drugs that are currently also used by vets (the patents have expired, so drug companies don't try to let people know about them now). They may also be available by different names (but same chemical names in different countries, and from US drug stores and vets). I recommend saving the below article and the articles at the links below for future reference. It has some known toxicities (see link about someone who had a reaction to it and died) but they say it is safer than the TB drugs they are using for active TB (I don't think I'd use it for dormant TB).

7500iu/d Vitamin D3 as Cholecalciferol gel caps (in MCT oil -- Country Life brand -- don't use dry powder as it isn't absorbed well) helps keep dormant TB from becoming active, as does healthy diet and lifestyle, along with adequate sleep, etc. Be sure to monitor serum calcium with higher amounts of D3, and take with vitamin K2 and fermented foods such as sauerkraut (with no preservatives -- just water, cabbage, salt). Many doctors recommend not taking more supplemental calcium than is found in a good quality multivitamin (Activite Sport from www.vitacost.com) and getting the rest from raw, organic greens, like cows and healthier aborigines do. You might also see my TB page on my website: www.distance-healer.com

- The Alliance for Natural Health USA - http://www.anh-usa.org -

Reader's Corner: Cheap and Effective TB Drug Being Ignored? Action Alert!
Posted By ANH-USA On January 15, 2013

A reader brought an interesting issue to our attention: mainstream medicine is rejecting a lifesaving tuberculosis treatment--likely because it's not profitable!

Steve wrote, "I am not a fan of Big Pharma, but you may be interested to know about a painkiller that kills TB." And indeed we were! We looked into the issue more and found another classic case of FDA red tape blocking access to a potentially lifesaving treatment.

Researchers have discovered [1] that an inexpensive, over-the-counter anti-inflammatory drug called oxyphenbutazone, developed in the 1950s to treat arthritis but withdrawn in the 1980s, can kill the bacteria that cause tuberculosis (TB)--even the drug-resistant varieties. In terms of over-the-counter pain relief, there are safer alternatives to oxyphenbutazone, as it does have some known toxicities [2]. However, when it comes to treating TB, oxyphenbutazone appears to be the safest treatment by a long shot [3].

The study was done by the Weill Cornell Medical College [4] at Cornell University and was funded in part by the TB Drug Accelerator Program of the Bill and Melinda Gates foundation. Researchers found it would cost about two cents a day to treat TB in developing countries, where the disease has reached pandemic proportions.

One in ten cases of TB is drug-resistant [5], it's second only to HIV as the leading infectious killer of adults worldwide [6] (as we reported last September), and it is the third largest cause of death among women aged 15 to 44. Influenza is in the news again (see our article in this issue), but TB is far more deadly. As the Wall Street Journal recently reported [7], India, the US, and South Africa are taking steps to address the threat of drug-resistant TB. The CDC has a faster test to diagnose drug-resistant strains, and the US is acting to alleviate shortages of TB treatments.

Unfortunately, it is unlikely that oxyphenbutazone will ever be used to treat TB patients. Companies won't pay for clinical trials, as they aren't likely to make a profit on a drug that's cheap. The drug has run out of its patent protection, so now nobody wants to study it, and while it is still used extensively in veterinary medicine [8], for it to be approved for TB, it would need to go through the extraordinarily expensive New Drug Application process.

Another obstacle is that the FDA requires testing on animals. When it comes to testing drugs, mice are by far the best (and cheapest) subjects [9]: they share 99% of their genes with humans. But mice metabolize the drug too quickly for it to be studied that way, so in this case, animal testing would be far more expensive than with other drugs. Besides, FDA-mandated clinical trials aren't always the best way to study new drugs. As we noted last year [10], they are also frequently misused, as Dr. Nicholas Gonzalez found during the clinical trials for his groundbreaking integrative cancer treatment.

(On a humorous note, at least oxyphenbutazone can be used in Scrabble. The word holds the title for the highest possible score for a single play under American tournament Scrabble rules, scoring 1,780 points across three triple-word-score squares, joining seven tiles to eight already played tiles.)

While a safe and effective and inexpensive TB drug goes begging, a potentially dangerous TB drug was just approved by the FDA [11]. Johnson & Johnson's new drug designed to treat multi-drug-resistant tuberculosis, benaquline, was given accelerated approval despite the FDA's findings that the drug comes with a fivefold greater risk of death compared to a placebo [12]. FDA usually requires three-stage testing process, but benaquline was approved after only the first two phases, with promises that they'd continue more tests later.

Why approve a drug that has a dramatically increased risk of death when a drug that has been around for half a decade can do the same thing more safely? Because the old drug costs pennies a day, while the new one is extremely expensive. Big Pharma is all about Big Money, and not about treating the millions of patients, most of them very poor, who are transmitting and then dying from the disease all over the world.

If we finally do get the worldwide pandemic that health experts have worried about for decades, and hundreds of millions of people die, it may very well be TB, not the flu. The people who run the drug system (whether in the pharmaceutical industry or the FDA) and are keeping oxyphenbutazone off the market may then lose loved ones and regret what they did--but it will be too late.

Action Alert! Contact the FDA, with a copy to Congress, and insist that a way be found around present bureaucratic barriers that prevent oxyphenbutazone from being reviewed for possible approval for drug-resistant tuberculosis. The threat of a worldwide pandemic in drug-resistant TB is very real. This is an urgent matter and there is no time to lose. Just because oxyphenbutazone is off-patent and therefore of little interest to drug companies and hard to study is no excuse. Send your message today!

Take Action! [13]
http://aahf.convio.net/site/Advocacy?pagename=homepage&id=1314

Article printed from The Alliance for Natural Health USA: http://www.anh-usa.org

URL to article: http://www.anh-usa.org/reader%e2%80%99s-corner-cheap-and-effective-tb-drug-being-ignored-action-alert/

URLs in this post:
[1] Researchers have discovered: http://www.pnas.org/content/early/2012/09/07/1214188109.full.pdf+html
[2] as it does have some known toxicities: http://www.elsevierbi.com/publications/the-pink-sheet/48/044/danbury-is-discontinuing-phenylbutazone-and-oxyphenbutazone
[3] the safest treatment by a long shot: http://www.eurekalert.org/pub_releases/2012-09/nyph-pdc091012.php
[4] Weill Cornell Medical College: http://weill.cornell.edu/news/releases/wcmc/wcmc_2012/09_10_12b.shtml
[5] One in ten cases of TB is drug-resistant: http://www.huffingtonpost.com/2012/09/11/oxyphenbutazone-pain-drug-resistant-tuberculosis_n_1875023.html
[6] leading infectious killer of adults worldwide: http://www.anh-usa.org/whats-the-biggest-world-pandemic-risk-today-untreatable-by-conventional-medicine/
[7] recently reported: http://online.wsj.com/article/SB10001424127887324461604578193611711666432.html
[8] still used extensively in veterinary medicine: http://articles.latimes.com/2012/sep/11/news/la-heb-tuberculosis-drug20120910
[9] mice are by far the best (and cheapest) subjects: http://sos.uga.edu/experiments.html
[10] As we noted last year: http://www.anh-usa.org/a-nutrition-treatment-for-pancreatic-cancer/
[11] potentially dangerous TB drug was just approved by the FDA: http://www.ipsnews.net/2013/01/controversial-anti-tb-drug-approved-in-u-s/
[12] despite the FDA's findings that the drug comes with a fivefold greater risk of death compared to a placebo: http://www.citizen.org/pressroom/pressroomredirect.cfm?ID=3786
[13] Image: http://aahf.convio.net/site/Advocacy?pagename=homepage&id=1314
[14] : http://www.silver-colloids.com/Reports
[15] : http://charles_w.tripod.com/tooth.html


Vitamin D scientifically shown to treat tuberculosis, significantly speed recovery time
by Jonathan Benson, staff writer
http://www.naturalnews.com/z037958_vitamin_D_tuberculosis_recovery_time.html

(NaturalNews) Exposing your skin daily to natural sunlight or regularly supplementing with high doses of vitamin D3 can effectively shorten the duration of tuberculosis infection. This is the finding of a new study recently published in the journal Proceedings of the National Academy of Sciences, which reveals once again that vitamin D plays a critical role in disease treatment and prevention.

Researchers from Queen Mary University (QMU) in London evaluated the power of vitamin D by giving it to several dozen tuberculosis patients at hospitals throughout the English city, and comparing how these patients fared to those not taking the hormone. They found that, compared to those taking just antibiotics, patients taking both antibiotics and vitamin D recovered more than 36 percent faster.

It turns out that vitamin D eases the inflammatory response associated with tuberculosis infection, and breaks down the scaffolding present in the lungs so that more white blood cells, which are what treats the infection, can make it through. This combined effect helps the body naturally eliminate tuberculosis infection much faster than it otherwise would with drugs alone, lessening the infection period from an average of 36 days to just 23 days.

"If we can help these cavities to heal more quickly, then patients should be infectious for a shorter period of time, and they may also suffer less lung damage," said Dr. Martineau about the spaces created in the lungs as a result of vitamin D. Though they are said to potentially harbor tuberculosis and other bacteria, these spaces are not really that serious of a problem since vitamin D appears to effectively eradicate any pathogens that might try to lodge inside them.

Since researchers did not compare the effects of treating tuberculosis patients with just vitamin D as opposed to vitamin D combined with synthetic antibiotics, it is unclear how much more effectively patients taking just vitamin D might have fared. Overuse of antibiotics, after all, is responsible for the emergence of deadly "superbugs," and may actually make infections more severe. (http://www.naturalnews.com/superbugs.html)

Vitamin D also shown to help prevent tuberculosis
As effective as it is at lessening the duration of tuberculosis, vitamin D may be an even better preventive method against tuberculosis, according to orofessor Peter Davies, also from QMU. Roughly 30 percent of people harbor latent tuberculosis in their lungs, and most of them never develop any negative symptoms. But supplementing with vitamin D could help the 10 percent that otherwise would develop full-blown tuberculosis to avoid the disease altogether.

Modern studies continue to prove that 'heliotherapy' has legitimate medical merit
Interestingly, the study actually brings tuberculosis treatment full circle, as light therapy, also commonly known as "heliotherapy," has been around for centuries as a treatment for tuberculosis (http://www.sciencemuseum.org.uk). Only within the past half century or so did light therapy lose popularity, and this due to the advent of synthetic antibiotics.

But now that antibiotics are being shown to spawn antibiotic-resistant superbugs, science is once again discovering that the simple, tried and true method of exposing skin to natural sunlight for the purpose of generating vitamin D is a powerful way to promote healing. The next step is for patients to ditch the antibiotics altogether and begin getting regular sunlight exposure or taking mega-doses of vitamin D.

Exposing your skin to anywhere between 15 minutes and one hour of natural sunlight a day, depending on your skin's pigmentation, is ideal for maintaining optimal vitamin D levels. If natural sunlight exposure is not an option, the Vitamin D Council suggests taking between 3,000 and 5,000 international units (IU) of vitamin D daily for optimal health. (http://www.vitamindcouncil.org)

Sources for this article include:

http://www.bbc.co.uk/news/health-19463105


Some Herbs and Supplements that help fight TB and help reduce the damage done by TB drugs (RIF - Rifampin, INH - Isoniazid, and others), including some that reduce mortality by 2.6 times (2600%) and make 80% of XDR and MDR TB respond to first line drugs when they formerly didn't (See Asterisk Key below for what the asterisks mean):

* 1 - P5P (active form of vitamin B6): helps prevent the neuropathy (nerve damage) caused by INH (Isoniazid)
www.vrp.com [1131, Vitamin B6 30 mg (from 50 mg Pyridoxal-5-Phosphate), 60 capsules]; 

* 1, 2 - Dandelion Root extract (3/d – careful if blocked gallbladder or gallstones) for liver support and detoxification, Swanson SW515; (detoxifies liver and increases bile; if you have gallstones, do a liver/gallbladder flush first)

* 2, 1 - Milk thistle full-spectrum extract, 3/d (I use a whole herb extract, not just Silymarin), www.swansonvitamins.com, SWH051, 250mg 80% + 250mg Milk Thistle Powder, supports liver, aids in detoxification, helps fight cancer. Note that milk thistle is oil-soluble, and is best taken with fatty food, oil and/or lecithin.

* 1TBS, 1TBS - non-GMO Lecithin Granules (2TBS/d with Milk Thistle, Aloe, other oil-soluble supplements to assist in their being absorbed by the body), http://www.vitaglo.com/2262.html 866-401-5402 [Now Vitamins brand Lecithin Granules- non gmo 2 lbs]

* 1tsp, 1tsp - Organic Extra Virgin Coconut Oil (keep in refrigerator; loosen a piece with a fork when needed),  www.iherb.com [JRW-16033, Jarrow Formulas Extra Virgin Coconut Oil, 16 oz (454 g), $7.80*.86=$6.71/ 16oz]

* 1,1 - Liver CS, http://thymic.com/liverplus.php, 800-556-5530 / 770-972-2129, Jill (je@thymic.com) Preventative Therapeutics, Inc. (protects liver)

* 1,1 - Livotrit Liver Protection by Biotics Research Canada for liver support and detoxification, (3/d), http://store.yahoo.com/spinelife/livotritplus.html http://store.yahoo.com/spinelife/livotritplus.html, http://store.yahoo.com/spinelife/biotics-research.html qty180 Livotrit Tablets $23.50; (spineliferewards101 for 10% discount; $8.95 Shipping if <$100) (protects liver)

* 1,1 - Artichoke extract Artichoke extract (Luteolin) (500mg twice a day – careful if blocked gallbladder or gallstones) for liver support and detoxification, iherb JRW-14062. This stimulates gall bladder to secrete bile which helps digestion and gets rid of liver toxins, so be careful if you have gallstones or it could rupture gallbladder. [iherb JRW-14062, 500mg, qty180, $17.37*.86=$14.94 (Note: You have to log into iHerb to see 14% discount; otherwise only 8%. Jarrow $14.97 at Vitacost, $14.45 at LuckyVitamin) (Make sure to set shipping or defaults to $12!]; http://www.luckyvitamin.com/p-20280-jarrow-formulas-artichoke-500-mg [63718, $16.02]; (detoxifies liver and increases bile; if you have gallstones, do a liver/gallbladder flush first)

* 3,3 - Andrographis extract (3,3 active TB; 2,1 Latent TB) works synergistically with INH, RIF; [See Buhner's Lyme bk: potentiates TB Rx's Rifampin & INH/isoniazid: p85, 89; Smilax p128, 131; Stephania root (careful about species -- get lab tested/verified or Mayway Stephania tetrandra; see Buhner) p151; Licorice root to balance it; Siberian Ginseng] [Siberian Ginseng + Andrographis greatly shortens  colds, flu & 200mg helps prevention per Buhner p86]; iherb [NWY-15381, Nature's Way Andrographis, qty60, 300mg 10% = 30mg extract + 100mg whole andrographis,  $8.12*.84 = $6.82]; http://www.vitacost.com/Natures-Way-Andrographis-Standardized [NTW 4153819, Nature's Way Andrographis Standardized -- 60 Vegetarian Capsules, $7.49]; http://www.luckyvitamin.com/p-4273-natures-way-andrographis-standardized-60-vegetarian-capsules [53116, Nature's Way Andrographis Standardized, 60 Vegetarian Capsules, $8.12];

* 1,1 - Siberian Ginseng - works synergistically with INH, RIF; iherb [PAR-77703, Paradise Herbs, Siberian Eleuthero Root, 60 Vcaps, $10.00*.86=$8.60]; http://www.vitacost.com/Paradise-Herbs-Siberian-Eleuthero-Root [PDH 4777036, Paradise Herbs Siberian Eleuthero Root -- 60 Vegetarian Capsules, $9.90]

* 1,1 - Cold Check pelargonium extract - works synergistically with INH, RIF; iherb [EUR-12006, Europharma Terry Naturally Cold Check!, 60 capsules, $15.96*.84=$13.4064];

Chewable DGL (Deglycyrrhizinated Licorice) - helpful if you have stomach upset from the TB prescription drugs (the ones that you have to take on an empty stomach, such as Isoniazid/INH, which is water-soluble; note that Rifampin/RIF is better absorbed with food as it is oil-soluble); http://www.vitacost.com/PlanetaryFormulasDGLDeglycyrrhizinatedLicorice  (PLF 8105015, $12.47, qty200)

* Artemisinin, 1/d; Caution: Not indicated for pregnant or nursing women.  Long term administration (greater than 2 or 3 months) should be monitored by a healthcare practitioner. Combining with antioxidants or iron may theoretically decrease effectiveness. Detoxification reactions may be experienced by some individuals. iherb [Doctor's Best Best Artemisinin, DRB-00170, 100mg, 90vcaps, $18.00; iherb [Allergy Research Group Nutricology Artemisinin, ARG-52160, 90vcaps, 100mg, $23.63]

* Pelargonium Cough Drops: Pelargonium Zand Zumka Herbalozenge, Cherry Menthol Flavor, 15 Homeopathic Lozenges (Pelargonium sidoides 1X, Mentholum 2X, Zincum Gluconicum 2X); for colds, cough, TB, sinusitis, pharyngitis, tonsillitis - reduces severity and duration; iherb [ZAN-96986, qty15, $1.60*.84=$1.344,  Mentholum 2X [relieves colds & cough], Zincum Gluconicum 2X [relieves cold symptoms]), ascorbic acid (vitamin C), brown rice syrup, herbal extract blend (eucalyptus, horehound, hyssop, licorice, mullein, peppermint, sage, slippery elm, thyme), natural cherry flavor, stevia leaf extract]; 

* Chinese Tea: see TB Chinese herbs section in the book, "The Treatment of Modern Western Diseases With Chinese Medicine" by Flaws & Sionneau; if you are going to use Chinese tea (decoction & infusion of Chinese herbs, see this book as there are 5 different formulas, depending upon your symptoms and how your body is reacting to the Tuberculosis. Add Smilax and Stephania to the tea, also.)

* Smilax - works synergistically with INH, RIF; (an herb to include in your Chinese Tea); www.nuherbs.com [P15830, Tu Fu Ling (Chinese Smilax Rhizome); [Tierra p80: 15-60g; 30g]

* Stephania tet. - works synergistically with INH, RIF; (an herb to include in your Chinese Tea); www.nuherbs.com [P15980 Fang Ji (Han) (Stephania Root); www.mayway.com [5746SF, PF Han Fang Ji (Stephania tetrandra), unsulfured herb]; [Tierra p106: 3-9g; 6-9g, don't take for a long time; is a diuretic; best to cycle it 1 month on and 1 month off (or 2wks on/2wks off); if you cycle it, it's okay to take for 6mos or a year]

** .5,.5 TBS - BCAA's - helps rebuild muscles and reverse wasting away of strength; Vitacost [NSI 3003655, NSI BCAAs (Branched Chain Amino Acids) -- 5,000 mg - 10.5 oz Powder, $14.99;

** 1,1 TBS or more - Organic Barley Grass powder - detoxifies toxins (drugs) and reduces damage to body & liver; www.iherb.com [NOW-02662, $38.56*.84=$32.39, 2lbs]; http://www.luckyvitamin.com/p-4560-now-foods-barley-grass-powder-organic-non-ge-2-lbs [from Kansas: 53381, NOW Foods - Barley Grass Powder--Organic, Non-GE - 2 lbs, $32.69];  organic non-GE, 2 lbs/87TBS. Barley Grass is a whole food grown and processed on fertile organic Kansas soil. Dehydrated whole leaf Barley Grass includes the natural juice and fiber found in Barley Grass. As a whole food, mix 1Tbsp in 8-12 oz. of water, fruit or vegetable juice. This amount provides the nutritional equivalent of a dark green leafy vegetable salad. [2 lbs (908 g); Serving Size 1TBS (10.44g), Servings Per Container: 87];

** .75,.75 tsp or more - Berry Green - detoxifies; Berry Green powder, http://www.vitacost.com/New-Chapter-Berry-Green-360g (2TBS/d in distilled water) iherb [NCR-00561, New Chapter Berry Green -- 360g, $58.47*.86=$50.28. Mix 1 TBS (6g)/d with 8 oz pure water. Refrigerate after opening. 1 TBS Servings per container: 60]

** .5,.5 tsp or more - Miracle Reds - detoxifies; Miracle Reds [iherb MGI-00108, Miracle Reds Antioxidant Superfood Supplement, 30 oz (850 g) $64.77*.84 = $54.41

2,2 - MHP Activite Sport mulitvitamin; very good quality Multivitamin/mineral with active forms of vitamins (people who are sick cannot convert many vitamins to their active forms) http://www.bulknutrition.com/?products_id=2330 [Activite Sport 120 Tablets $18.84]; http://www.vitacost.com/MHP-Activite-Sport [MHP 2200026, MHP Activite Sport -- 120 Tablets, $20.80]; http://www.luckyvitamin.com/p-3512-mhp-activite-multi-vitamin-120-tablets [52230, MHP - Activite Multi-Vitamin - 120 Tablets, $21.98; serving: 4 tablets; 30 servings / bottle];

** Magnesium Citrate powder, Swanson NOW-01295 (5/8tsp 1 time a day in PM) [I use 500mg of malate in morning and 500mg of citrate in evening, mixed in my green drink with distilled water, barley grass, Berry Green, Miracle Reds, Magnesium Ascorbate, etc.] [w/Activite: 0 AM, 5/8tsp PM (MgCitrate 393.75 + MgMalate 400 + Activite 100 + 225 Mg Ascorbate = 1118.75mg total)]

Vitamin D3 (5000iu/d) in oil gel cap; don't take too much supplemental Calcium (check serum calcium) - helps overcome TB (remember how the sanitariums put the patients out in sunlight? Also, if immigrants from hot climates take D3, fewer of them will convert from Latent to Active TB after 3 months, as they typically do when they move to colder climates.)

1, 1 - Vitamin K2 (15g/capsule); Vitamin K2 as MK7, 1/d http://www.vitacost.com/NSI-Vitamin-K-Complex-Vitamin-K2-as-Menaquinone-7-MK7-400-mcg-180-Softgels [NSI 3007325] (K2 inhibits cancer cell growth and promotes cancer-cell suicide, puts calcium back in bones and teeth instead of soft tissues and arteries (works with D3): http://wrightnewsletter.com/2010/04/15/vitamin-k/)

1,1 - Lithium Orotate - helps regrow grey matter of brain (particularly helpful for encephalitic TB (TB in the brain); www.vrp.com [7241, Lithium Orotate, 120 capsules; Lithium Orotate (providing 4.8mg elemental lithium)

Specific blenderized organic vegetables - for good nutrition, weight gain, health, detoxification (see my RawFoods page: www.distance-healer.com/24.html)

1,1 - Devil's Claw if needed for joint pain; iherb [NWY-61000 Nature's Way Devil's Claw Standardized, 90 Capsules, 350mg 1.5% plus 180mg whole herb, $11.69*.84=$9.82]; http://www.luckyvitamin.com/p-5525-natures-way-standardized-devils-claw-90-capsules [54731, Nature's Way Standardized Devil's Claw, 90 Capsules, $11.69];

* 3,3 - IACC Immune Assist Critical Care Chinese medical mushroom extract (immune booster); www.alohamedicinals.com, 877-835-6091 or 775-886-6300

1 - Thymulus - Thymus immune system booster; Thymulus, 1/d, http://www.vitacost.com/Enzymatic-Therapy-Immune-Strong-Wellness-Booster-Formerly-Thymulus  [ET 040063];

** Fucoidan, 0.5 to 1 capsule (open and mix into glyco drink) - works with the other glycos to modulate immune system; Fucoidan, iHerb DRB-00165, immune booster

** Glyconutrients - modulate immune system (helps it to recognize friend or foe): this is a mixture of Gum Ghatti (if available) + Arabinogalactan + Aloe Vera that you put in your green drink with barley grass, Berry Green, Miracle Reds, Magnesium Citrate powder, etc. and distilled water; the other glyconutrients that work together with this are in capsule form and are mentioned below.

Glyconutrients - Gum Ghatti [1-2tsp/d] + high quality Arabinogalactan powder [3-5tsp/d; less when cancer no longer active or gone -- helps against liver metastasis and boosts immune system] + long-chain 200:1 Aloe Vera Powder [1-3tsp/d; less when cancer no longer active or gone] in bulk at a discount from mbullers@optonline.net, CSR Health & Nutrition, LLC -- email him for prices) These are some of the things I mix in my green drinks. Arabinogalactan is especially important when you want to prevent liver metastasis or treat tumors already in liver. Dramatically inhibits even more aggressive cancers from metastasizing; works better with above immune boosters (fucoidan, aloe, Thymulus, ProBoost, astragalus, echinacea, goldenseal, etc. The above "sugars that heal", including aloe, fucoidan, echinacea, goldenseal, etc. (technically, "polysaccharides", are different from harmful sugars that feed cancer; they're used by the body to recognize "friend" or "foe". Info at: http://www.nutrientsforhealth.com/ and http://www.glycoinformation.com/sugars.html ) Since these immune stimulants all work by different mechanisms, it's important to use several specific ones. You can make your own, if you'd like: http://www.burnoutsolutions.com.au/glyconutrients.htm) Note: Aloe is better absorbed when taken with a fatty meal and/or lecithin granules. Note for men battling prostate cancer: I would avoid taking any Chondritin Sulfate (for arthritis), since this can stimulate prostate cancer (since the prostate contains receptors for chondroitin).

Arabinogalactan, http://www.betterlife.com/prod_home_page.asp?prod_id=16813 (.5,.5 tsp/d or more if really sick) http://www.vitacost.com/FoodScience-Arabinogalactan-Powder [$17.16, 100g, 20 servings of 1 scoop] (or you can get this from Mike Bullers above); (One of the Glycos that works together with the other glyconutrients)

optional: Aloe Vera capsules (long chain), http://www.vitacost.com/New-Chapter-Aloe-Vera-200 (2/d)
http://www.vitacost.com/New-Chapter-Aloe-Vera-200  [CH 005106, New Chapter, $19.17, 60 Tablets, 300mg Organic freeze-dried Aloe Vera juice concentrate (leaf)(200:1)(equal to 2 oz. [60 grams] of fresh aloe vera juice)(min. 32% total polysaccharides - 96 mg, 45% short-chain polysaccharides - 43 mg, and 55% long-chain polysaccharides - 53 mg)] [http://www.longevityplus.net/store/product.php?productid=461&cat=6&page=1 (Aloe Immune, per Dr. Rowen)] (One of the Glycos that works together with the other glyconutrients)

long-chain 200:1 Aloe Vera Powder (.25,.25 tsp/d or more if really sick); Dr. David Wheeler's MPS Gold: http://www.0disease.com/0dietary_molecularchart.html; http://www.0disease.com/0order.html; http://www.0disease.com/mpsgoldbasics.htm; Retail pricelist: http://www.0disease.com/pricelist.htm; http://www.0disease.com/0sweethealth.html; Dr. David Wheeler and his staff: by email at wheeleroffice@aol.com or by telephone toll free in the USA at 800-760-3530 or 888-342-6772 and international at 503-771-6943 9am to 5pm PST;  (One of the Glycos that works together with the other glyconutrients)

Fucoidan, iHerb DRB-00165, (2/d), immune booster  (One of the Glycos that works together with the other glyconutrients)

Astragalus, iHerb Paradise Herbs, PAR-77727 (2/d), immune booster (One of the Glycos that works together with the other glyconutrients)

1,1 - Fennugreek capsules or powder, http://www.vitacost.com/Planetary-Herbals-Full-Spectrum-Fenugreek [PLF 8105282, Planetary Herbals Full Spectrum Fenugreek -- 600mg - 120 Tablets, $6.38; Fenugreek Seed Extract (4:1) 400mg; Fenugreek Seed 200mg]; iherb [PTF-10528, Planetary Herbals, Fenugreek, Full Spectrum, 600 mg, 120 Tablets, $7.75*.84=$6.51]; One of the glyconutrients, immune booster & helps lungs;  (One of the Glycos that works together with the other glyconutrients)

1 - Fo Ti/ He Sho Wu - helps keep your hair from turning grey (a side effect from TB drugs for some people) [iherb [PAR-77731, Paradise Herbs, Fo Ti, 60 Veggie Caps, $15.00]

1 - Magnolia if needed for sleep [http://www.hfn-usa.com/shop/cart.php?m=product_detail&p=43  (Magnolia Max, 100mg 90%, qty60, $19.95)]

1 to 3 - Melatonin - antioxidant (take at bedtime) [Swanson Melatonin, SW502, qty120, 3mg, $3.29]

2 to 3 g/day - Vitamin C as Magnesium Ascorbate - antioxidant [http://www.luckyvitamin.com/p-7755-now-foods-magnesium-ascorbate-powder-8-oz (56976, $11.43)];

1.5 to 2 g/d - Bioflavonoids (70% as much as vitamin C) - antioxidants [Swanson, SW128, $8.39, qty250 capsules, 750mg, Bioflavonoids]

1,1 - Zyflamend - reduces inflammation (CRP), joint and muscle pain dramatically; take in the middle of meals (not on empty stomach or you'll feel a "warming" sensation from the oregano, basil, etc. oils) [iherb [NCR-04054, New Chapter Zyflamend, 120 hexane-Free Softgel Capsules NC-4054 $39.62*.84 = $33.28]

1500mg Curcumin + 1500mg Quercetin + 1.5-1.75 TBS per day of molecularly-distilled Fish Oil - reduces inflammation, pain (split into 2 or 3 dosages; mix in saucer & eat with spoon or sprouted bread)

Fish Oil (molecularly-distilled to remove heavy metals and PCBs) taken with full-spectrum vitamin E, curcumin, quercetin and hesperidin powders: 500mg each time (i.e., 1500mg/d) of 95% Curcumin, 500mg of quercetin and 1 capsule (open it) of hesperidin dissolved in 2tsp (2TBS/d) liquid fish oil (molecularly-distilled to remove heavy metals and PCBs) 3 times a day. Also take 1/d full-spectrum vitamin E. Open capsules and mix in well using small bowl and spoon. 2TBS/day liquid fish oil (if that is not enough oil to dissolve the curcumin, quercetin and hesperidin, add some EV Olive Oil to the fish oil). [Some supplements, including these, are oil soluble and will not be absorbed if swallowed with water: see Dr. Blaylock's book pp 14-15]. See below for sources and amounts of above. (Note: Jon Barron, Dr. Blaylock and others have noted that people who are ill, overweight, middle-aged or elderly, or who eat a lot of omega-6 oils/fats tend to lack enough enzyme to convert the ALA in flaxseed oil to EPA/DHA, so I use purified fish oil directly, as the unconverted ALA causes inflammation and increased, rather than decreased cancer)

Fish Oil: www.iherb.com [NTA-26137, Nature's Answer, Liquid Omega-3 Deep Sea Fish Oil EPA/DHA, Natural Orange Flavor, 16 fl oz (480 ml), $14.99, 4/$58.46 [DHA has the more powerful anticancer effect and it is especially efficient in preventing cancer of the colon, prostate and breasts. Pure DHA is derived from algae, and an adult dose is 500 mg. a day. For children ages 2 to 12, the dose is 100 mg. a day. DHA inhibits cancer using a number of mechanisms — principly inflammation reduction. Most of the others are beyond the scope of this newsletter. For more information on this and other cancer treatment topics, see my book, Natural Strategies for Cancer Patients.]

Curcumin 95% (3x500mg/d mixed well in oil -- see Dr. Blaylock's email below) plus http://www.luckyvitamin.com/790011140764.html , 888-635-0474

Hesperidin (2x500mg/day mixed into fish oil with curcumin & quercetin), Swanson [SW1097, Swanson Premium Hesperidin, 500mg 60Caps, $5.49;

Quercetin/Bromelain, http://www.vitacost.com/NSI-Quercetin-Bromelain (6/d in oil)

Ginger, www.swansonvitamins.com NW486 (3/d) anti-inflammatory and also good for nausea/upset stomach [this is oil-soluble, so I open and mix the powder from these capsules in my fish oil, although they can be taken with food or even water for nausea]

1 - 400iu extra Full spectrum vitamin E in addition to what is in Activite Sport (it's necessary to take this extra vitamin E if you take fish oil - helps prevent fish oil from oxidizing in your body); Vitamin E (800 iu/d full spectrum oil soluble); Swanson SWU209 (1-2/d)

Sources for the above are:
iherb = www.iherb.com
Vitacost = www.vitacost.com
BL = www.betterlife.com
Swanson = www.swansonvitamins.com
LV = www.luckyvitamin.com

Asterisk Key:
*= take 1-2 hours before and 1 hour after INH/RIF so that it works with the drugs and reduces the liver damage from the drugs. "2,1" means take 2 before and 1 after, etc. Two hours or more after a meal (since Isoniazid is water-soluble and is best taken on an "empty" stomach) I would chew and swallow 1 TBS of non-GMO Lecithin granules, then take the first dose of the single-asterisked supplements with a minimal amount of water (since they're oil-soluble), followed by teaspoon or so of organic EV Coconut Oil. After waiting 30 minutes, I'd take the Isoniazid with some (distilled non-chlorinated non-fluoridated) water. One hour after that, I'd take the second dose: 1 TBS Lecithin, then the 2nd dose of the single-asterisked supplements, then either another teaspoon of Coconut Oil or some fat-containing food (since you can eat one hour after taking Isoniazid). "1,1" for Zyflamend means to take 1 with each of two meals (Zyflamend doesn't have an asterisk next to it, so it just means to take some at two different times)

** = mix these together into distilled water and drink
---

From Healing Lyme by Stephen Buhner:

Andrographis is synergistic with Rifampin and Isoniazid and decreases mortality from TB 2.6 times (2600% -- see p85,89); Smilax (p128,131); Stephania root (Stephania tetrandra, p151); Siberian Ginseng (PFHH Tuberculosis by Balch p389); you could add some Licorice Root to balance the other herbs in the tea (decoction / infusion).
---

Note: take B6 if you are taking Isoniazid -- at a different time from the Isoniazid or INH -- as it depletes it and can cause nerve damage/neuropathy.
---

Primer: An Introduction to Herbal Medicine Techniques
http://www.motherearthliving.com/health-and-wellness/primer-choosing-and-using-medicinal-herbs-5.aspx
http://www.motherearthliving.com/print.aspx?id={7582421B-F83B-4AFA-B584-63884058F5BA}
How use herbs and how to make decoctions, infusions, tinctures, teas, etc.

Take the Confusion Out of Infusion: How to Make an Elderflower Infusion (or other Infusions)
http://www.motherearthliving.com/natural-health/natural-cold-remedies-make-elderflower-infusion.aspx


Chinese Herbal (TCM) Books:

See the TB Chinese herbs section in the book, "The Treatment of Modern Western Diseases With Chinese Medicine" by Flaws & Sionneau for the different types of symptoms that various people exhibit when they have TB, and which herbs each type should take (there are several different Chinese herbal formulas depending upon which set of symptoms you have).

The Way of Chinese Herbs (TWoCH) - Tierra
- Contraindications (which herbs not to use together) TWoCHp620
- Lung Yin Deficiency p46-56

The Chinese Herbalist's Handbook (TCHH) - Ehling
- Disharmonies and Syndromes Index section (can look up Food Stagnation, Kidney Yin Deficiency, etc.) TCHH p763 (or see Tierra V1)

Chinese Traditional Herbal Medicine (CTHM) - Tierra (V1 & V2; e.g., V1p269)
- Spleen info CTHM V1p269
- Fast Pulse, agitated deep pulse v1p221
- Heat v2p103

Healing Lyme by Stephen Buhner (has very important information about TB)

Prescription for Herbal Healing (PFHH) by Phyllis Balch

From Healing Lyme by Stephen Buhner:
Andrographis is synergistic with Rifampin and Isoniazid and decreases mortality from TB 2.6 times (2600% -- see p85,89); Smilax (p128,131); Stephania root (Stephania tetrandra, p151); Siberian Ginseng (PFHH Tuberculosis by Balch p389); you could add some Licorice Root to balance the other herbs in the tea (decoction / infusion).

Get organic, lab tested herbs -- especially for Stephania, since a mistake in species could be fatal (don't get tea pills or powder, as they cannot be identified). extracts are not lab tested for heavy metals, pesticides, and species (which is important especially for Han Fang Ji (Stephania tetrandra) because mistakes in species have killed people due to kidney failure, so lab-tested whole herbs best).

(nuherbs P10450) Chuan Xin Lian (Andrographis) 2lbs [Tierra: 9-15g; Henry said: 15g -- with this, reduce the 400mg 10% capsules (as well as other herbs for which we are taking capsules) by half from 6 to 3/d, Henry (a Chinese herbalist) said]

(nuherbs P15830) Tu Fu Ling (Chinese Smilax Rhizome) 4lbs [Tierra p80: 15-60g; Henry said: 30g]

(nuherbs P12475) Wu Jia Shen (Siberian Ginseng) 2lbs [Tierra p112: 3-12g; Henry said: 12-15g]

(nuherbs P13030) Gan Cao (Chinese Licorice Root) 1lb [Tierra p190: 2-9g; Henry said: 9g]

(nuherbs P15980 Fang Ji (Han) (Stephania Root))(mayway 5746SF) PF Han Fang Ji (Stephania tetrandra), unsulfured herb 1lb $8.00 [Tierra p106: 3-9g][Henry: 6-9g, don't take for a long time; is a diuretic; best to cycle it 1 month on and 1 month off (or 2wks on/2wks off); if you cycle it, it's okay to take for 6mos or a year]

Make sure that you use Han Fang Ji -- NOT Guang Fang Ji -- Stephania is often being substituted with lethal herb Guang Fang Ji. Plum Flower from MayWay safer according to Stephen Buhner in Healing Lyme bk)[Careful: common mistake is substituting guang fang ji, which contains Aristolochic Acid and causes kidney failure] (mayway 5746SF) (nuherbs P15980); Buhner p153 says that PF/Plum Flower brand is stringently tested, and says that all manufacturers' LAB TESTED versions of stephania in U.S. are being tested to make sure that guang fang ji isn't being substituted for for han fang ji). Perhaps it's best to get Plum Flower Stephania]

From Healing Lyme by Stephen Buhner, the following herbs kill TB and decrease mortality, as well as work synergistically with the prescriptions: Andrographis is synergistic with Rifampin and Isoniazid and decreases mortality from TB 2.6 times (2600% -- see p85,89); Smilax (p128,131); Stephania root (Stephania tetrandra, p151); Siberian Ginseng (PFHH Tuberculosis by Balch p389); you could add some Licorice Root to balance the other herbs in the tea.

Andrographis (Chuan Xin Lian) [Tierra: 9-15g; Henry said: 15g -- with this, reduce the 400mg 10% capsules (as well as other herbs for which we are taking capsules) by half from 6 to 3/d, Henry said] v2
(nuherbs P10450) Chuan Xin Lian (Andrographis) 2lbs [Tierra: 9-15g; Henry said: 15g -- with this, reduce the 400mg 10% capsules (as well as other herbs for which we are taking capsules) by half from 6 to 3/d, Henry said]

Chinese Smilax Rhizome (Tu Fu Ling) [Tierra v2p80: 15-60g; Henry said: 30g]
(nuherbs P15830) Tu Fu Ling (Chinese Smilax Rhizome) 4lbs [Tierra p80: 15-60g; Henry said: 30g]

Siberian Ginseng (Wu Jia Shen); PFHH kills drug resistant TB [Tierra v2p112: 3-12g; Henry said: 12-15g]
(nuherbs P12475) Wu Jia Shen (Siberian Ginseng) 2lbs [Tierra p112: 3-12g; Henry said: 12-15g]

* cycle it *
Fang Ji (Han) (Stephania Root) Han Fang Ji (Stephania tetrandra)[Tierra v2p106: 3-9g][Henry: 6-9g, don't take for a long time; is a diuretic; best to cycle it 1 month on and 1 month off (or 2wks on/2wks off); if you cycle it, it's okay to take for 6mos or a year]
(nuherbs P15980 Fang Ji (Han) (Stephania Root))(mayway 5746SF) PF Han Fang Ji (Stephania tetrandra), unsulfured herb [Tierra p106: 3-9g][Henry: 6-9g, don't take for a long time; is a diuretic; best to cycle it 1 month on and 1 month off (or 2wks on/2wks off); if you cycle it, it's okay to take for 6mos or a year]

Chinese Licorice Root (Gan Cao) [Glycyrrhiza spp.; Radix] v2p190
(nuherbs P13030) Gan Cao (Chinese Licorice Root) 1lb [Tierra p190: 2-9g; Henry said: 9g]

Sweet Wormwood - Artemisia annua (Qing hao) 3-9g v2p84

Asparagus root - Asparagi Cochinchinenis (Tian men dong) 6-18 v2p219

Fresh Ginger (Sheng Jiang) [Zingiber officinale; Rhizoma] 3-9g v2p26 (quells inflammation) Note: NuHerbs doesn't carry this (only dried); if you need fresh, get it at Whole Foods, etc.
Notes: Fresh Ginger (Sheng Jiang) Warms the Exterior, while Dried Ginger (Gan Jiang) Warms the Interior. It is added to any formula where there is Spleen and Stomach Coldness which can manifest as abdominal pains, vomiting, diarrhea, loose stool, poor appetite. v2p27 Fresh Ginger is beneficial for digestion and assimilation (goes to the Stomach and Spleen). Dried Ginger is Hotter and more of a metabolic stimulant.]

Frankincense/Boswellia carterii resin (Ru xiang) (quells inflammation); Tierra v2p165,166 3-9g

Note: The drug Isoniazid / INH depletes Vitamin B6 and can cause nerve damage/neuropathy. Take 50mg of Vitamin B6 (the active form, Pyridoxal 5-Phosphate/ P5P is better, if you can get it) if you are taking Isoniazid / INH: take it at a different time from the Isoniazid.

Zyflamend (www.iherb.com [search for NCR-04054] or www.vitacost.com/New-Chapter-Zyflamend) reduces the inflammation in your legs, lungs, bones / muscles from TB; if Zyflamend's too expensive or not available where you live, you can take the individual herbs or oils of the ingredients instead (or make a decoction/infusion of them and drink the herbal tea from them); see the above links for a list of Zyflamend's ingredients.

Another anti-inflammatory is 1 TBS liquid fish oil (purified / molecularly-distilled to remove heavy metals, PCBs, etc.) into which you've mixed 500mg Curcumin + 500 Quercetin twice a day (works best when you also take the Zyflamend).

Taking some Vitamin K2 (a little is found in sauerkraut, but best to take capsules, too) helps keep your calcium in your bones and not your soft tissues.

Artemisinin (Sweet Wormwood / Artemisia annua) helps with TB. Long term administration (greater than 2 or 3 months) should be monitored by a healthcare practitioner. Detoxification reactions may be experienced by some individuals (Healing Crisis or Herxheimer Reaction) which means that you want to help your body detoxify by drinking more pure water, raw organic vegetables, deep breathing, sweating, etc.  Either add bulk Chinese herb Sweet Wormwood - Artemisia annua (Qing hao), or you can use capsules of Artemisinin [Doctor's Best Artemisinin, www.iherb.com, DRB-00170, 100 mg, 90 Veggie Caps, $17.60.  Caution: Not indicated for pregnant or nursing women. Long term administration (greater than 1 month) should be monitored by a healthcare practitioner and include liver enzymes and hemoglobin testing]

Standard Process Pneumotrophin PMG 90T / Biotics Research Pneuma-Zyme (http://www.spinelifestore.com/pneumpmg.html (Pneumotrophin PMG 90T, Item# 6900 Spinelife.com, qty90, $13.65; spineliferewards101 for 10% discount, also Free S&H if >$100)

Avoid iron, especially from red meat (makes TB grow 12 times faster)! Note that taking iron (or food containing iron) with vitamin C increases the absorption of the iron, while taking the iron or food with green tea extract or organic green leafy vegetables decreases the absorption. (Eating specific Vitamixed blenderized vegetables is suggested; see Raw Food sectiion on my website more).  Also, don't eat a lot of Arginine or arginine-containing foods (see PFHH article below), and other foods that increase inflammation (e.g., omega-6 oils such as vegetable, corn, canola, safflower, sunflower, soybean, etc. oils; sugar; white starch).

Siberian Eleuthero Root [e.g., www.iherb.com, PAR-77703, Paradise Herbs, Siberian Eleuthero Root] 1 capsule twice a day (works synergistically with the drugs to help kill TB)

Andrographis [e.g., www.iherb.com, NWY-15381, Nature's Way Andrographis] 3 capsules twice a day (works synergistically with the drugs to decrease mortality from TB 2600%)

Sublingual Vitamin B12 and sublingual glutathione help support the lungs and body.

Valerian can help with the nervousness that the prescription drugs cause some people to feel.

Drink plenty of pure water to help with the dryness/thirst that the drugs cause.

Enzymes: Pancreatin [www.luckyvitamin.com, 56682, NOW Foods Pancreatin 4X 500 mg. - 250 Capsules, $13.91; www.iherb.com, NOW-02946, qty250, $17.83] and Serrapeptase [www.iherb.com, DRB-00190, Doctor's Best Serrapeptase, 270 Veggie Caps] taken at least 1 hour before or 2 hours after food) may help to digest the coating that TB bacteria have that allows them to survive despite the immune system trying to kill them.

Be careful not to lose too much weight: healthy fats (extra virgin olive oil, etc.), proteins and some whole or sprouted grains (that are not ground -- whole wheat bread raises serum glucose as much as white bread because it's ground) and lots of raw, organic vegetables (blenderized, with EV olive oil and pure water added, are best: see my website Raw food page for details).

Glyconutrients (aloe inner leaf gel / extract, brown seaweed extract / fucoidan, arabinogalactan and gum ghatti) help modulate the immune system, reduce inflammation and recognize and fight pathogens.
---

From PFHH pp412-413 re Tuberculosis:

Tuberculosis (TB) is a chronic disease caused by the bacterium Mycobacterium tuberculosis. Scientists estimate that as many as two billion people worldwide have been infected. Tens of thousands of cases have recently appeared in the United States, generally in people whose immune systems have been weakened by HIV infection.

TB is passed when bacteria are released during coughing, sneezing, and speech. Symptoms include chronic cough with blood in the sputum, fatigue, fever, night sweats, weight loss, and general malaise. In some people, the disease becomes inactive. In others, it takes an active form and can cause severe lung damage. TB also can start tissue damage in the adrenal glands, bones, chest cavity, kidneys, eyes, sex organs and throat.

TB bacteria are first met and engulfed by immune system cells called macrophages. The bacteria can survive this process, but as long as they are confined to the macrophages, no symptoms occur. Once the macrophage dies and the bacterium escapes, though, the rest of the immune system sends out huge numbers of fresh immune-system cells to destroy the TB. In the process, nearby healthy tissues are also destroyed. (Note: taking the wrong immune boosters can increase this damage).

Combination antibiotics are needed to control TB. Although herbal treatments can help TB, they are most useful in increasing the effectiveness and diluting the side effects of standard treatment.

Beneficial Herbs:

Bletilla 
Use under professional supervision. Reduces sputum production, coughing, and spitting and coughing of blood. Reduces swelling and inflammation. Don't take Aconite with Bletilla (per Kathryn at www.elixirs.com)

Cardamom or fennel seed
Tincture: take 10 drops in 1/4 cup water 3 times daily. Tea bags: take 1 cup 3 times daily. Increases effectiveness of streptomycin against TB. Do not use fennel seed if you have an estrogen-sensitive disorder, such as breast cancer, endometriosis, or fibrocystic breast disease.

Coptis
Capsules: take no more than 250mg daily for 3 months. Reduces coughing and spitting of blood; mildly antibacterial. Do not take coptis for longer than 2 weeks at a time. Do not use it if you are pregnant or have gallbladder disease. Do not take this herb with (i.e., at the same time as) supplemental vitamin B6 or with protein supplements containing the amino acid histamine. (You need to take B6 if you are taking Isoniazid -- at a different time from the Isoniazid or INH -- as it depletes it and can cause nerve damage/neuropathy).

Lentinan (Chinese mushroom extract)
Injection or powder: use under professional supervision. Acts against drug-resistant TB. Reduces likelihood of spreading disease to others.

Siberian Ginseng
Eleutherococcus senticosus tincture (or extract capsules): take as directed on the label. Suppresses multiplication of TB bacteria. Do not take siberian ginseng if you have prostate cancer or an autoimmune disease, such as lupus or rheumatoid arthris.

Herbs to Avoid:

People who have TB infection should avoid the following immune-stimulant herbs: American ginseng, ginseng (Panax), ligustrum, psoralea, saw palmetto, and Solomon's seal. (For more information regarding these herbs, see the individual entries under The Herbs in Part One).

Formulas:

Minor Bupleurum Decoction
plus
Tonify the Middle and Augment the Chi Decoction (Ginseng & Astragalus Combination / Bu Zhong Yi Qi Tang v2p324 & v2p41)
Two traditional Chinese herbal formulas that when combined enable people to take multiple forms of chemotherapy simultaneously. Especially helpful for people who also have either HIV or hepatitis B.

Ophiopogonis Decoction
A traditional Chinese herbal formula traditionally used for coughing and spitting of saliva, dry and uncomfortable sensation in the throat, dry mouth, red tongue, shortness of breath, and wheezing. Do not take Ophiopogonis if you have a fever.

Recommendations:

Continue taking all prescribed medications even if you feel well. Medical treatment is essential to avoid spreading TB to family members and friends. (Members of your household may have to take medication even if they test negative for the disease). Continued treatment is also necessary to avoid drug resistance (see under Considerations).

To ensure adequate supplies of vitamin D, which suppresses the growth of TB bacteria, get at least 20 minutes of (off-peak) sun exposure on your face and hands each day. If that is not possible, take 400 to at most (1000 iu) 5000 iu of vitamin D supplements (in oil) each day. [Note: check vitamin D and serum calcium blood levels to make sure that you're not getting too much D3 or calcium.]

Avoid all iron supplements and iron-rich foods. Stored iron can increase the rate at which TB bacteria multiply twelvefold. People infected with both TB and HIV must scrupulously avoid both iron supplements and iron-rich foods, including organ meats and all red meat. HIV infection increases the body's storage of iron in immune cells, and teh additional iron greatly accelerates the multiplication of TB. Excessive dietary fat aggravates this effect. Taking vitamin C at the same time also increases absorption of iron; IP6 (also depletes good minerals), green tea and green leafy vegetables reduce absorption of iron.

Avoid foods containing the amino acid arginine, which accelerates the growth of TB bacteria. Foods that contain arginine include chocolate, almonds, peanuts, and most other nuts.

Avoid stress.

Get adequate rest and fresh air, preferable in a dry climate.

Considerations:

TB is usually treated with a number of antibiotics at once. In a small number of people -- especially in thos who start, but do not finish, a couse of treatment -- the germ becomes resistant to antibiotics. The problem of durg resistance has become so widespread that doctors now often treat TB with chemotherapy, which controls TB without activating immune responses that destroy tissue.

People who have TB should not use cortisone preparations. Cortisone suppresses immune function and makes the infection more difficult to treat.
---

From Kathryn Jones DiHom, M. Ed., Health Counselor (www.elixirs.com) 800-390-9970 (509-766-0182) 10am-5pm Pacific Time M-F or leave a message, (consult@elixirs.com):

Quebracho 30C (good for coughing, lungs)
Celletech's Upper Respiratory 6C (contains Celletech's Lung)
Tuberculinum 30C, 1M, 50M, CM (100M), 10MM
Another series: 200C, 10M, 500M, MM
1LM = 1:50,000 dilution. She has LM 1-53 of Tuberculinum; homeopaths usually do a series of 4, starting in the middle, then jump and do another series of 4 until they get a response (and then loop through the ones that give a response?); e.g., LM12-15, 22-25, etc.
---

Spleen info Tierra V1p269

From Chinese Traditional Herbal Medicine Vol. II by Michael Tierra, p389-390:

TB presents typical Yin Deficient symptoms such as dry chronic cough, sometimes with blood, weight loss, five burning spaces Heat, night sweats, fevers and chills. TCM describes it as a condition of Lung Yin Deficiency (Deficient Lung Yin V1p265) and treatment is considered only mildly effective.

Anyone suspected of or possibly exposed to TB should undergo a medical skin test (PPD). Once an individual has TB, their skin test will remain positive for life. Ultimately, the most successful treatment of this disease is through prevention by identifying those who carry TB.

Chinese herbal treatment for tuberculosis is not very effective, but the primary herbal formula to consider is Lily Bulb Decoction to Consolidate the Lungs (Bai he gu jin tang) [see below for ingredients].

Other formulas that can be considered are:

1. Minor Bupleurum Combination (Xiao chai hu tang) is a primary formula because it both clears Heat and inflammation and tonifies Deficiency and wasting. It can be used simultaneously with any other formula. Try to get lab-tested (for heavy metals, pesticides, sulfur and correct species -- mistaken species whose names sound alike have caused deaths) Chinese herbs, and make a decoction from the bark & roots, and add the leaves/flowers at the end (infusion). If you get powdered extract (make sure that it is tested: Mayway carries some lab-tested herbs), you can dilute it in water or mix it in the tea. (Tierra V2p341; V1p213 wet cough with thick mucous)

2. Ophiopogon Combination (Mai men dong tang) is indicated for Lung and Stomach Yin Deficiency (see Tierra V1 and also The Way of Chinese Herbs by Tierra) with symptoms of dry mouth and throat. [See Tierra V2p220: Ophiopogon is specific for Deficient Lung and Stomach Yin as well as Heart Yin, since it is able to relieve mental irritability (one of the symptoms of Heart Yin Deficiency). At the same time, it acts as a mild expectorant, clearing Hot Phlegm while lubricating the Lungs. For Dryness and Heat of the Lungs with dry cough and possible blood tinged sputum, combine Ophiopogon (Mai Men Dong), Glehnia (Sha Shen), Asparagus (Tian Men Dong), Tendrilled Fritillary root (Chuan Bei Mu) [v2p117] and Unprepared Rehmannia root (Sheng Di Huang) [v2p56]; for Deficient Stomach Yin [v1p298] the same combination is used without the Fritillary root (Chuan Bei Mu). For more, see Tierra V2p220; also V1p214 dry cough]. (Tierra V2 p346 & V1 p177; see also Tian men dong V2p219)


VITAMIN D CAN HEAL TUBERCULOSIS?
By Dr. James Howenstine, MD.
September 2, 2008
http://www.newswithviews.com/Howenstine/james69.htm

Tuberculosis remains a serious health problem around the world. In 2003 it was estimated that 1,700,000 persons died from tuberculosis. Many of these deaths occurred in persons suffering from HIV infections who had badly damaged immune systems.

The traditional drugs (isoniazide, streptomycin, rifampin, ethambutol, pyrazinamide, ethionamide, cycloserine) used to treat tuberculosis have been handicapped by the mycobacterium tuberculosis organisms’ ability to develop bacterial resistance. To compound this problem, many of the drugs used in tuberculosis therapy have significant side effects which commonly cause patients to drop out of treatment programs. Therapy for drug-resistant tuberculosis patients may take 18 to 24 months to complete and can cost $250,000 annually. Few countries can afford this expense. The term XDR-TB has been applied to patients who are resistant to first and second line tuberculosis drugs.

Many patients and physicians are terrified of tuberculosis because the disease is contagious. Unfortunately, there is a social stigma associated to tuberculosis which frequently causes an individual to lose nearly all their friends when word gets out that they have the disease. The incidence of tuberculosis is increased by poverty, overcrowding, alcoholism, HIV, and drug addiction.

Lack of vitamin D has always been found among the elderly and the housebound. Deficiency of vitamin D is related to higher rates of breast, ovary, colon, and prostate cancer; increased incidence of multiple sclerosis, progression of osteoarthritis, impairment of the immune response, high blood pressure, mood disorders including serious depression, Type 1 diabetes, and tuberculosis. Lack of vitamin D appears to be a prime factor in the rising incidence of depression along with a lack of omega 3 fatty acids. Patients with Parkinson’s Disease, multiple sclerosis, congestive heart failure, and Alzheimer’s Disease have all been found to have significant deficits of vitamin D.

New Ideas about Vitamin D

Influenza has long been considered to be an epidemic disease that appears in the middle of the winter. This happens to be the exact time when skin exposure to vitamin D production would be at the lowest levels in the whole year in the northern hemisphere. The possibility has been raised that perhaps the reason influenza is able to spread in an epidemic fashion in the winter was because natural immunity from vitamin D production was at its lowest level of the whole year in the winter, and not because a new strain of influenza always managed to develop during the winter season.

A second important aspect of vitamin D relates to decreased vitamin D production in persons who have dark pigmented skin when compared to lightly pigmented individuals Dr. Plotnikoff of the Univ. of Minnesota Medical School measured 25(OH)D [calcidiol] blood levels [1] in a chronic pain clinic. He discovered that 100% of Black, Hispanic, East African, and American Indians were vitamin D deficient. 93% of all patients were vitamin D deficient. Young women in their child-bearing years were at the greatest risk for not being diagnosed. Many of these patients had been having pain for years without ever having vitamin D levels checked. This suggests that chronic musculoskeletal pain is often caused by vitamin D deficiency.

The rate of prostate cancer in black males is 3 times higher than that of white males of equal age in the US. This may be in large part be explained by lower vitamin D levels in blacks.

Advanced Drug Resistant Tuberculosis

Tuberculosis that has become resistant to antibiotic therapy presents a very difficult situation for the clinician. The drugs used to treat this condition are very toxic, quite expensive, and not universally effective. Often patients refuse to remain on the therapy because of serious side effects including hearing loss, dizziness, kidney damage and liver injury.

Umckaloabo Therapy of Tuberculosis

Charles Stevens contracted a serious form of tuberculosis in 1897 at age 17 while residing in South Africa. He made a dramatic recovery [2] after being started on the herb umckaloabo from the root of the plant pelargonium reniforme. A second patient, 26 year old Morris Vaughn, was in Talgarth Sanitarium in Wales dying from bilateral tuberculosis. He frequently coughed up bloody sputum. After deciding to try umckaloabo he proceeded to recover and was able to obtain life insurance, marry, and teach chemistry until age 65. He died of heart failure at age 77.

Umckaloabo [3] was successfully used by a friend for a patient who had extra pulmonary tuberculosis in Chennai, India. She noticed that his fever, back pain, and blood sugar values improved after starting umckaloabo therapy, whereas there had been no change in his condition with either first or second line tuberculosis drugs. His disease was located in dorsal and lumbar spine, pleura, endobronchial, and hilar lymph nodes.

The knowledge that drug resistance has not interfered with the effectiveness of umckaloabo as a tuberculosis therapy after 101 years of usage is important.

This herb has been a safe, established therapy for bronchitis in children for more than fifty years in Germany. During this time, drug resistant tuberculosis has been a major worldwide problem.

Chemistry and Pharmacology

The bioactive ingredients of Preniforme (umckaloabo) are the tri- and tetra-oxygenated coumarins, gallic acid, and gallic acid methyl ester (polyphenols), as well as various flavinoids. It also has high levels of calcium and silica. Extracts of the root have been available in German pharmacies since 1985 without prescription and have found widespread use against infections of sinuses, throat, and respiratory tract. However, it has been shown that pelargonium sidoides [4] was even more effective in treating these problems.

The alcoholic extract of the has three primary effects:

1. Anti-bacterial: The umckaloabo extract prevents bacteria from attaching to cells in the mucous membranes.
2. Anti-viral effect: Umckaloabo prevents viruses from attaching to the mucous membrane cells and stimulates the body immune cells so that bacteria and viruses are prevented from multiplying.
3. Expectorant: The extract acts as an expectorant which allows the body to expel contaminated mucous. This makes their replication more difficult. With the properties of being bacteriostatic and immune modulating Umckaloabo appears to a good alternative to treating respiratory illnesses with antibiotics.

Normal Dosage:

Adults in the acute stage of infection should take 20 to 30 drops three times daily. Children 6 to 12 years old take 10 to 20 drops three times daily, while children from 6 months to 6 years take 5 to 10 drops daily.

Umckaloabo can be purchased in Germany and the US. This would be a sensible approach for the individual with advanced tuberculosis. The German source for Umckaloabo is Apoteke Hamburg (phone 01149 40335333). Speak with Doris Bruehl. The US source for umckaloabo is the African Red Tea Company (phone 323-658-7832). Umckaloabo is much safer, less expensive, and more effective than the conventional therapy for drug resistant tuberculosis.

The knowledge that drug resistance has not interfered with the effectiveness of umckaloabo as a tuberculosis therapy after 111 years of use is important.

Current Concepts about Vitamin D Dosage

The currently recommended daily dosage of 400 IU of vitamin D daily appears to be unreasonably low when we know that a light skinned individual makes 20,000 units [5] of vitamin D within 15 to 20 minutes of whole body exposure to the summer sun (before redness appears). This 20,000 IU of vitamin D is five times the amount of vitamin D considered capable of initiating toxic reactions by the Institute of Medicine, demonstrating that these guidelines are set far too low. Dark skinned individuals need 5 to 10 times longer in the sun to produce an equivalent amount of vitamin D as Caucasians, depending on the extent of their pigmentation.

Blood levels of calcidiol below 35 are found in 70% of U.S. citizens. Normal values are considered to be between 35 and 50 ng/ml. Life guards and outdoor persons living near the equator have values near 50 ng/ml. Toxicity from excess vitamin D does not occur from sunlight because ultraviolet light degrades vitamin D after 20,000 units have been produced, thus leading to a steady state with no toxicity.

New Ideas about the Effects of Vitamin D in Tuberculosis

Gujarati Asians living in London have a high prevalence of both vitamin D deficiency and tuberculosis. The persons with the lowest levels of vitamin D have the highest incidence of tuberculosis. Patients with no detectable value for vitamin D had a tenfold higher incidence of tuberculosis [6] than patients who had low levels of vitamin D. Tuberculosis itself does not appear to lower vitamin D levels.

Indonesian scientists [7] treated 70 tuberculosis patients with 10,000 units of vitamin D daily over a 9 month treatment program. All the patients made complete recoveries.

Persons of African descent are more susceptible to tuberculosis than Caucasians, with higher rates of infections and more severe cases. Sub-Saharan Africa has the world’s highest per-capita rates of tuberculosis and death from tuberculosis, with numbers nearly twice as high as any other region of the world.

Research from UCLA [8] and the Harvard School of Public Health revealed that vitamin D plays a key role in the production of a molecule called cathelicidin, which kills the mycobacterium tuberculosis organism. Vitamin D is produced when sunlight contacts the skin. Melanin pigment is abundant in dark skin and functions to reduce damage from ultraviolet light, and to decrease the amount of vitamin D formed in the skin.

Dr. Robert Modlin, lead investigator of the UCLA research team, stimulated gene receptors and then analyzed the resulting genetic responses. They found activation of the monocytes of vitamin D receptor (VDR) previously known to be associated with antimicrobial activity. A second genetic activation involved gene Cyp which causes an enzyme to convert vitamin D to its active form, 1-25-dihydroxyvitamin D3 (1-25 D3). The gene which encodes vitamin D receptors was expressed on the surface of macrophages. Activation of this receptor changed vitamin D from a passive to an active form. This newly activated vitamin D sliced a pre-existing protein in two. One of the resulting chunks of protein is the tubercle bacillus killer cathelicidin.

Serum produced by Afro-Americans produced 63% less cathelicidin than serum donated by whites. Adding a vitamin D precursor to the African-American serum increased cathelicidin production. Dean of the Harvard School of Public Health Barry Bloom found these results exciting because they suggested that a dietary supplement costing only pennies a day (vitamin D) might turn out to be able to reduce the frequency and severity of a deadly disease (tuberculosis).

Vitamin D mediates a key human bacterial response against tuberculosis. This could explain why African-Americans are more vulnerable to tuberculosis as they have lower levels of vitamin D than Caucasians. This series of molecular events provides an explanation of why dark-pigmented patients are vulnerable to a more virulent form of tuberculosis.

The ready availability of inexpensive vitamin D and the herbal substance umckaloabo provide two new encouraging approaches to the therapy of tuberculosis.

Footnotes:

1, Plotnikoff, GA and Quigley BA Prevelence of Severe Hypovitaminosis D in patients with Persistent, non specific Musculoskeletal Pain Mayo clinic proc. 2003;78: 1463-1470
2, Newsome SWB Stevens’ cure:a secret remedy J R. Soc. Med 2002, 95:463-7
3, Harris, Ruth Personal communication supplied th information about the improvement of extrapulmonary tuberculosis and how to obtain umckaloabo in the USA and Germany.
4, Phytophaemaka VII Oct 2001
5, Vitamin D Council 9100 San Gregorio Road, Atascadero, Ca. 93422
6, Lancet Vol 355 No. 9204 19 Feb. 2000
7, Acta Med Indos. Jan-Mar 2006;36(1):3-5
8, Liu p.T. et al Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response Science February 23, 2006

© 2008 Dr. James Howenstine - All Rights Reserved



 
 
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